玉美人传媒

Facult茅 de m茅decine Facult茅 de m茅decine

Translational Chronobiology and Chronomedicine

The group of Prof. Charna Dibner contributes to translational chronobiology and chronomedicine by developing two major lines of research:

1)    Studying the properties of α- and β-cell oscillators and their impact on islet function and β-cell regeneration in physiology and diabetes; This strand aims to establish the cell-specific circadian molecular landscape of mouse and human pancreatic islets. To gain new insights into the circadian organisation of α- and β-cells, they combine multi-omics and mechanistic studies in advanced genetic rodent models and in human islets.

2)    Unravelling the role of clock dysfunction in the pathophysiology of human metabolic diseases and cancer. This line of research, conducted in diverse human cohorts and primary cells, explores the molecular basis of circadian dysregulation associated with diabetes and cancer. It has direct clinical relevance by exploring the potential of clock components and clock-controlled genes and metabolites as diagnostic biomarkers and therapeutic targets for managing these diseases.

Her recent and ongoing studies have been awarded the ISREC Tandem Grant for translational cancer research and the Leenaards Prize for translational research project.

SPECIFIC EXPERTISE

The core competence of her group is the application of molecular chronobiology to human immuno-metabolic diseases and cancer (translational chronobiology and chronomedicine). They have developed advanced genetic mouse models to study circadian regulation of inflammation and metabolism, as well as advanced approaches to study molecular clocks and their immuno-metabolic outputs in human primary tissues. By combining multi-wearable and multi-omics approaches, they have provided in-depth characterisation of circadian rhythms and various outputs of patient cohorts (Phillips et al., Diabetologia, 2024), which they are currently applying to different cohorts of patients. Finally, they have developed an in-house horizontal continuous perifusion system that allows continuous measurement of human cytokine secretion from different tissues/cell types (Perrin et al., MolMet 2015; Petrenko et al., JoVE, 2016).        

SELECTED PUBLICATIONS

  1. Wang C., Zeng Q., Cheng P., Wang S., Bill R., Wu Y., Naulaerts S., Barnoud C., Pick R., Gul Z., Cenerenti M., Hsueh P.C., Moller S.H., Sun M., Su Z., Jemelin S., Petrenko V., Dibner C., Hugues S., Jandus C., Li Z., Ho P.C., Garg A., Simonetta F., Pittet M., Michielin O., Scheiermann C. (2024). . Cell, 187(11), 2690-2702.e17. doi:10.1016/j.cell.2024.04.015.
  2. Sinturel F., Chera S., Brulhart-Meynet M.C., Paz Montoya J., Stenvers D.J., Bisschop P.H., Kalsbeek A., Guessous I., Jornayvaz F.R., Brown S.A., D’Angelo G., Riezman H., Dibner C. (2023). . Cell Reports Medicine, 4(11), 101299. doi:10.1016/j.xcrm.2023.101299.
  3. Andersen P., Petrenko V., Rose P., Koomen M., Fischer N., Ghiasi S., Dahlby T., Dibner C., Mandrup-Poulsen T. (2020). . International Journal of Molecular Sciences, 22(1), 83. doi:10.3390/ijms22010083.
  4. Petrenko V., Stolovich-Rain M., Vandereycken B., Giovannoni L., Storch K.F., Dor Y., Chera S., Dibner C. (2020). . Genes and Development, 34(23-24), 1650-1665. doi:10.1101/gad.343137.120.
  5. Dibner C. (2020). . Acta Physiologica (Oxford), 228(1), e13281. doi:10.1111/apha.13281.