The biology of an obligate intracellular parasite
Her laboratory has addressed fundamental questions in the biology of Apicomplexa related to invasion and egress from the infected cell. This complex event touches upon the actomyosin system for parasite motility, the contribution of adhesins and the importance of processing as well as the biogenesis of secretory organelles and regulation of their exocytosis. The parasites secrete proteins into the host cells that subvert their function, including the neutralisation of host cell autonomous and innate immunity defence mechanisms.
Her group is combining state-of-the-art genetic approaches with in-depth cellular and molecular phenotyping to investigate various aspects of the cell biology of the parasite in interplay with the host. More recently, the group is conducting a distinct line of research to unravel the molecular mechanisms governing cyst wall formation and subversion of host cellular functions during encystation, as well as the metabolic needs and capabilities of the parasite in function of its niche.
SPECIFIC EXPERTISE
Her laboratory has acquired additional sets of expertise, including computational modelling, metabolomics, lipidomics and advanced imaging technologies both in tissue culture and applicable to animal infection.
SELECTED PUBLICATIONS
. Krishnan A, Kloehn J, Lunghi M, Chiappino-Pepe A, Waldman BS, Nicolas D, Varesio E, Hehl A, Lourido S, Hatzimanikatis V, Soldati-Favre D. Cell Host Microbe. 2020 Feb 12;27(2):290-306.e11. doi: 10.1016/j.chom.2020.01.002
. Boillat M, Hammoudi PM, Dogga SK, Pagès S, Goubran M, Rodriguez I, Soldati-Favre D. Cell Rep. 2020 Jan 14;30(2):320-334.e6. doi: 10.1016/j.celrep.2019.12.019
. Sardinha-Silva A, Mendonça-Natividade FC, Pinzan CF, Lopes CD, Costa DL, Jacot D, Fernandes FF, Zorzetto-Fernandes ALV, Gay NJ, Sher A, Jankovic D, Soldati-Favre D, Grigg ME, Roque-Barreira MC. PLoS Pathog. 2019 Jun 21;15(6):e1007871. doi: 10.1371/journal.ppat.1007871
. Hammoudi PM, Jacot D, Mueller C, Di Cristina M, Dogga SK, Marq JB, Romano J, Tosetti N, Dubrot J, Emre Y, Lunghi M, Coppens I, Yamamoto M, Sojka D, Pino P, Soldati-Favre D. PLoS Pathog. 2015 Oct 16;11(10):e1005211. doi: 10.1371/journal.ppat.1005211
. Kemp LE, Yamamoto M, Soldati-Favre D. FEMS Microbiol Rev. 2013 Jul;37(4):607-31. doi: 10.1111/1574-6976.12013. Epub 2012 Dec 27. PMID: 23186105
6 Nov 2020