Jorge Larios
Proteins belonging to the ESCRT complexes are known as membrane remodeling factors, which regulate events such as cytokinesis, virus budding and multivesicular endosome (MVE) formation. Specifically, CHMP proteins (ESCRT III complex) are known as the key proteins in membrane deformation processes. 听However, in mammalian cells, the exact mechanism by which recruitment of the ESCRT proteins to biological membranes occurs is not clear. 听In order to better understand the role of ESCRT proteins, I am working with mammalian cells and in vitro assays using ESCRT recombinant proteins. In addition, I am interested in finding new proteins and lipids which could facilitate the recruitment of ESCRT proteins to the endosomal membranes.
I am a joined PhD student working in the laboratories of Dr. Aur茅lien Roux and Dr. Jean Gruenberg since September 2013. Before coming to the 玉美人传媒 I did my undergraduate and master鈥檚 degrees in Biochemistry at the Pontificia Universidad Cat贸lica de Chile. Here, I worked in the Cell Biology department with Dr. Mar铆a Paz Marzolo, and my research was focused on the study of the endocytic protein trafficking of receptors belonging to the low-density lipoprotein receptor family.
I am currently studying the role of the ESCRT proteins in the endosomal pathway of mammalian cells.
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